Sundararajan Venkatesan


	Sundararajan Venkatesan Head, Molecular Cell Biology Unit Laboratory of Molecular Immunology (LMI) NIAID Bldg. 10, Rm. 6A05 National Institutes of Health Bethesda, MD 20892-1576 Tel. 301-496-6359 FAX 301-402-4122 E Mail: aradhana@helix.nih.gov or sv1s@nih.gov Sundararajan Venkatesan is a board certified anatomic and clinical pathologist (1977) from the University of Pittsburgh Health Center. He has been a scientist at the National Institutes of Health since 1977 and was tenured in 1984. Over the may tears at the NIH, he has supervised a medium-sized group working on several contemporary areas of molecular biology and gene expression, enzymology, human virology, AIDS pathogenesis, receptor biology and proteomics. He has published numerous papers on the genetic organization and regulation of expression of DNA (poxvirus), RNA (paramyxovirus), and retroviruses (HIV). The fellows he trained have gone on to develop productive careers in academia and industry. Professional Status Licensed MD, Commonwealth of PA Pathologist, AP & CP, American Board of Pathology Certified in 1977 Molecular Biologist Virologist M.B.B.S. (1968) M.S. (Phys. Chem), S.U.N.Y., NY, 1972. Major Research Interests HIV gene interactions with cellular proteins and organelles with emphasis on immune-modulation and receptor signaling Cell Biological & Biochemical Aspects of Chemokine Receptor Signaling Chronology of Career & Research Summaries 7/1998 - Present NIAID, NIH, Bethesda MD Medical officer & Group Leader Molecular Biology of Chemokine Receptor with respect to HIV usage & Signaling Modulation by HIV proteins. Modulation of vesicular trafficking dynamics by HIV-1 Nef protein with emphasis on CD4 and HLA-I receptors. Design micro-chips for studying specific RNA:protein interactions using biosensor (SPR) technology. HTS screening of inhibitors of RNA and DNA binding by specific proteins using SPR technology. Similar HTS screening of potential chemokine receptor agonists and antagonists. Genomics and proteomics screening of cells infected with HIV or expressing specific HIV proteins. 7/1989 - Present NIAID, NIH, Bethesda MD Medical Officer & Group Leader Molecular Biology of HIV Gene Regulation & AIDS Pathogenesis & Immunology. During this period, led a group of 26 scientists and published numerous papers on several aspects of HIV virology and AIDS pathogenesis. 7/1981 - 7/1989 NIAID, NIH, Bethesda MD Expert & Principal Investigator As a principal investigator on tenure track (equivalent to assistant professor in the academia), conducted numerous research projects to understand the lifecycle of various human viruses including parainfluenza and HIV viruses. Also served as a hospital pathologist on an ad-hoc basis at the NIH Clinical Center. 7/1977 - 7/1981 NIAID, NIH, Bethesda MD Senior Staff Research Fellow & Expert During this period, served as a research associate and developed novel projects pertaining to Vaccinia virus Biology and Nucleic Acid Enzymology. 7/1974 - 7/1977 University of Pittsburgh School of Medicine, Pittsburgh PA Sarah Mellon Scaife Fellow & Teaching Instructor Taught human pathology courses to medical, dental and nursing students. Served as a research associate in pathology and developed projects pertaining to biochemical aspects of experimental fatty liver. Was instrumental in executing seminal work concerning eukaryotic gene expression. 7/1972 - 7/1976 University of Pittsburgh School of Medicine, Pittsburgh PA Resident in Pathology Served as a medical intern for one year (1972- '73) at the U. Pittsburgh Health Center Hospitals, followed by residency in Pathology. Was appointed a Chief resident in Pathology in 1976. Supervisory Experience Supervised 75 scientists at various levels including 36 post-doctoral fellows and 4 graduate students. Peer Reviewer: AIDS J.; AIDS & Human Retroviruses; Biochemistry, Biotechniques, Blood, Chemistry & Biology, J Biol Chemistry; J. Clin. Inv.; J. Exp. Med.; J. General Virology; J. Virology; Mol Biol of the Cell; Mol Cell Biol.; Mol. Pathol.; Proc. Natl. Acad. Sci. USA; Traffic; Virology; Virus Research

Head, Molecular Cell Biology Unit Laboratory of Molecular Immunology (LMI) NIAID Bldg. 10, Rm. 6A05 National Institutes of Health Bethesda, MD 20892-1576 Tel. 301-496-6359 FAX 301-402-4122 E Mail: aradhana@helix.nih.gov or sv1s@nih.gov

Sundararajan Venkatesan is a board certified anatomic and clinical pathologist (1977) from the University of Pittsburgh Health Center. He has been a scientist at the National Institutes of Health since 1977 and was tenured in 1984. Over the may tears at the NIH, he has supervised a medium-sized group working on several contemporary areas of molecular biology and gene expression, enzymology, human virology, AIDS pathogenesis, receptor biology and proteomics. He has published numerous papers on the genetic organization and regulation of expression of DNA (poxvirus), RNA (paramyxovirus), and retroviruses (HIV). The fellows he trained have gone on to develop productive careers in academia and industry.

Professional Status Licensed MD, Commonwealth of PA

Pathologist, AP & CP, American Board of Pathology Certified in 1977

Molecular Biologist Virologist

M.B.B.S. (1968)

M.S. (Phys. Chem), S.U.N.Y., NY, 1972.

Major Research Interests

HIV gene interactions with cellular proteins and organelles with emphasis on immune-modulation and receptor signaling

Cell Biological & Biochemical Aspects of Chemokine Receptor Signaling

Chronology of Career & Research Summaries

7/1998 - Present NIAID, NIH, Bethesda MD

Medical officer & Group Leader

Molecular Biology of Chemokine Receptor with respect to HIV usage & Signaling Modulation by HIV proteins.

Modulation of vesicular trafficking dynamics by HIV-1 Nef protein with emphasis on CD4 and HLA-I receptors.

Design micro-chips for studying specific RNA:protein interactions using biosensor (SPR) technology. HTS screening of inhibitors of RNA and DNA binding by specific proteins using SPR technology. Similar HTS screening of potential chemokine receptor agonists and antagonists.

Genomics and proteomics screening of cells infected with HIV or expressing specific HIV proteins.

7/1989 - Present NIAID, NIH, Bethesda MD

Medical Officer & Group Leader

Molecular Biology of HIV Gene Regulation & AIDS Pathogenesis & Immunology.

During this period, led a group of 26 scientists and published numerous papers on several aspects of HIV virology and AIDS pathogenesis.

7/1981 - 7/1989 NIAID, NIH, Bethesda MD

Expert & Principal Investigator

As a principal investigator on tenure track (equivalent to assistant professor in the academia), conducted numerous research projects to understand the lifecycle of various human viruses including parainfluenza and HIV viruses.

Also served as a hospital pathologist on an ad-hoc basis at the NIH Clinical Center.

7/1977 - 7/1981 NIAID, NIH, Bethesda MD

Senior Staff Research Fellow & Expert

During this period, served as a research associate and developed novel projects pertaining to Vaccinia virus Biology and Nucleic Acid Enzymology.

7/1974 - 7/1977 University of Pittsburgh School of Medicine, Pittsburgh PA

Sarah Mellon Scaife Fellow & Teaching Instructor

Taught human pathology courses to medical, dental and nursing students.

Served as a research associate in pathology and developed projects pertaining to biochemical aspects of experimental fatty liver. Was instrumental in executing seminal work concerning eukaryotic gene expression.

7/1972 - 7/1976 University of Pittsburgh School of Medicine, Pittsburgh PA

Resident in Pathology

Served as a medical intern for one year (1972- '73) at the U. Pittsburgh Health Center Hospitals, followed by residency in Pathology.

Was appointed a Chief resident in Pathology in 1976.

Supervisory Experience

Supervised 75 scientists at various levels including 36 post-doctoral fellows and 4 graduate students.

Peer Reviewer:

AIDS J.; AIDS & Human Retroviruses; Biochemistry, Biotechniques, Blood, Chemistry & Biology, J Biol Chemistry; J. Clin. Inv.; J. Exp. Med.; J. General Virology; J. Virology; Mol Biol of the Cell; Mol Cell Biol.; Mol. Pathol.; Proc. Natl. Acad. Sci. USA; Traffic; Virology; Virus Research