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First NameAnu
Last NamePuri
Designation/Position/RoleStaff Scientist
Institute/OrganisationNCI-Frederick, NIH
Office Address/Locationbldg 469/rm 216A, P.O. Box B,Miller drive
E-mailapuri@helix.nih.gov
Phone301-846-5069
Fax301-846-6210
Websitehttp://ccr.nci.nih.gov/staff/staff.asp?profileid=6797
ExpertiseMy area of research focuses on the mechanisms of entry pathways of enveloped viruses. Using cell biological, biophysical, biochemical approaches, I have studied the assemblies of molecular scaffolds of viral proteins and their receptors. Enveloped animal viruses deliver their genetic material to the cell by fusion of their membranes with those of the target cell. I have examined fusion mechanisms of members of rhabdo, orthomyxo, paramyxo and retrovirus family. My interest lies in elucidating the regulation of membrane fusion by plasma membrane lipid counter parts. The knowledge gained from my research has implications in the design of inhibitors of viral entry and the development of vaccines that prevent viral infection. 
Recently I have embarked upon the development of lipid-based nanoparticles for delivery of toxic drugs. I plan to develop liposomes bearing payload of drugs with imaging and targeting capabilities. My focus is to modify the building blocks of liposomes (phospholipids) to generate these particles, which will result in on-demand triggered release potential. My long-term goal is to develop these state-of the art liposomes compatible for delivery of anti-cancer agents to patients.
 

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